الفهرس 
Hypertension in Elderly.Only 14 pages are availabe for public view
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Abstract
The prevalence of hypertension is growing rapidly in both developing and developed countries and the worldwide estimates of its prevalence are expected to rise.
Atherosclerosis is one of the most important and common causes of death and disability throughout the world. Most cardiovascular morbid events are the consequence of atherosclerosis.
Many factors related to the development, outcome, and prevention of atherosclerosis in cerebrovascular, aortic, renal, and peripheral arterial territories are shared with coronary atherosclerosis.
With ageing the size of the aorta increases with a normal expansion rate of about 1–2 mm/year involving all segments.
C-reactive protein (CRP) is a marker of systemic inflammation and has emerged as an interesting novel and potentially clinically useful marker for increased cardiovascular risk.
This thesis was conducted to study the relationship between the aortic root dimensions, coronary risk factors, CRP and echocardiographic changes among asymptomatic hypertensive elderly and the possibility of using CRP as a predictor of atherosclerosis.
A case-control study was performed on 90 elderly subjects will be recruited they were subdivided into 3 groups:
- Group 1: 30 elderly male patients suffering from hypertension.
- Group 2: 30 elderly female patients suffering from hypertension.
- Group 3: 30 controls without any health problems.
All groups were recruited from the inpatients wards and outpatients clinics in Ain Shams University Hospital Informed oral consent was taken from all the 90 subjects.
All subject were subjected to Comprehensive geriatric assessment, blood pressure measurement, trans-thoracic echocardiography to measure aortic root dimensions, abdominal duplex scanning to measure the aortic root diameter at bifurcation of Aorta, coronary heart disease risk assessment, by measuring Lipid profile (including total cholesterol, HDL- cholesterol, triglycerides, LDL- cholesterol) and high sensitivity C-reactive protein (hsCRP) then Global Coronary heart disease risk assessment was done by Framingham risk score (FRS) and Reynolds risk score (RRS).
This study showed that hypertensive elderly patients had significantly higher aortic root diameter at the thorax.
There was no significant difference between cases and control groups as regard the studied coronary risk factors. However when applying global risk assessment scores (FRS & RRS) hypertensive subjects had higher risk than controls.