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Abstract pesticides are double edged weapons. they are considered to be the unavoidable heavy cost of cevilization. This research was done to spot light on the normal development of the testis pre-and post- natally and compare it with that under the effect of malathion pes- ticide. 252 rats were used at di fferent ages. They were classified into 9 groups; 8 of which to cover all stages of testicular development, while male fertility was tested in the 9th group. Each group was dividerl into a control and an experimental subgroups. The experimental subgroups were subjected to different diluted doses of 57% malathion (J /l 0, 1/20 and 1/30 of LD50). Rats were weighed at the start and at the end of the experiment. Group 1 supplied control and treated foeti at different ages till control and treated newlyborns obtained. In Group 2, 3, 4, & 5 postnatal rats were treated with 1/30 LD50 of malathion orally for different periods. In group 6 pubertal rats were given orally 1/30 LD50 malathion every other day for 50 - 90 days. In group 7 and 8, postpubertal rats were given orally (I/IO and 1/20 LD50” of malathion) every other day for 60 - 90 days. in the last groupj9j the ability of the treated adult males to impregnate females, was tested. Morbidity and mortality were recorded in all groups. |