الفهرس 
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Abstract
The present work was performed to study the effect of amaryl and
propolis in the treatment of diabetes mellitus and hyperglycemia
induced by using alloxan. Moreover the side effects of these drugs
were studied.
This study was carried out on one hundred New Zealand
rabbits weighing 500 gm were divided to main 6 groups to study the
antidiabetic activity and side effect of amaryl and propolis.Ten rabbits
kept as - ve control (gp.l) .Sixty rabbits were divided into 3 groups
(gps.2,3 and 4) to study the antidiabetic activity of drugs ,each group
contaning 20 rabbits and all sixty rabbits in the three groups following
a 48h fast, were injected liP with alloxan at a dose of (50 mg / kg
b.wt) freshly dissolved in sterile saline (50 mg/rnl),then injected IN
with 10 ml of glucose 5% and kept on drinking water supplemented
with 10% glucose for the first 24 h after the alloxan injection .Within
7 days after alloxan injection, diabetes mellitus was confmned by the
demonstration of hyperglycernia (blood glucose concentration was
measured using the glucose oxidase method). Animals with blood
glucose concentrations less than 250 mg/dl and died animals were
excluded from the study.Diabetic rabbits in gp.(2) kept without
treatment all over the experimental periods as +ve control, while
diabetic rabbits in gp.(3) were treated orally with amaryl by the
therapeutic dose for 2 months and diabetic rabbits in gp.( 4) were
treated orally with propolis by the dose 53.3 mg/kg b.wt for 2
months.The remaining thirty rabbits were divided into equal 2 groups
(gps.5 and 6) to study the side effect of drugs. Gp. (5) orally given
amaryl as gp. (3) and gp. (6) orally given propolis as gp.(4) .Drugs
were given in gps.(3-6) using an esophageal tube.In all groups, blood