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Abstract Monosodium glutamate is a sodium salt derivative of a natural amino acid called glutamate. Monosodium glutamate is almost completely tasteless by itself. What it does is to enhance the flavors of certain savory or meaty foods by awakening special taste buds on the tongue. It is thought that a fifth taste sense called umami is responsible for the pleasant flavor of a steak or vegetables in a savory sauce.The use of monosodium glutamate is very controversial in recent years. It has been reported that MSG has neurotoxic effects lead to brain cell damage, retinal degeneration, endocrine disorder and some pathological conditions such as addiction, stroke, epilepsy, neuropathic pain, schizophrenia, depression, Parkinson`s disease, Alzheimer`s disease and amyotrophic lateral sclerosis.MSG consumption have some deleterious effect on the cells of the cerebellum and by extention may affect the functions of the cerebellum.Ascorbic acid protects against the toxic neurological symtoms that arise from a high MSG dose. It can prevent and cure MSG toxicity.The present study was carried out to investigate the effects of MSG on the cerebellum of albino rats and the role of ascorbic acid against MSG`s toxicity..The albino rats were chosen for this work. As regards the offspring albino rats, they were kept on breast feeding with their mothers in healthy conditions from the first day of life. |