الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Silver nanoparticle have been prepared through the reduction silver ion by sodium borohydride .This is one of the simplest cheapest process for obtaining silver nanoparticle. UV/Vis spectroscopy reveals the surface plasmon property while TEM image reveal the nanonature of the prepared samples.
The yellow colloid Ag NPs was used for the binding with
drugs (DHPT, 4HPACM, 5ASA). The fluorescence properties of functionalized Ag NPs binding with drugs were observed at excitation wavelength ex 400 nm and emission wavelength em 466 nm. The analysis of the functionalized Ag NPs binding with drugs (DHPT, 4HPACM, and 5ASA) was based on the effect of fluorescence intensity enhancement when drugs (DHPT, 4HPACM, 5ASA) interacted with Ag NPs.
Ag NPs binding with drugs was carried out in aqueous solution and the maximum fluorescence intensity occurred when the range 5.4, 0.28 and 0.97 mg/l for nanosilver particles of 10, 5.5 and 2.5 nm sizes, respectively.
The nanosilver was used for determination of (DHPT, 4HPACM, and 5ASA) in commercial pharmaceutical samples. (DHPT, 4HPACM, and 5ASA) concentrations determined using this method is in good agreement with declared values. The proposed low cost chemical sensor could find application in the measurement of DHPT, 4HPACM, and 5ASA level in clinical samples as well as in pharmaceutical industry.