الفهرس 
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Abstract
The present work comprises preparation of nine new benzimidazole ligands H3L1, H4L2, H3L3, H3L4, HL5, H2L6, H3L7, H2L8, H3L9. The resulting ligands were characterized by elemental analyses and spectral studies (IR, NMR, UV and mass spectroscopy). Moreover, some transition metal complexes of these ligands were prepared by the reaction of some transition metal ions (Ag(I), Cu(II), Fe(III), Ru(III), Pt(II), VO(II), Ni(II) and Zn(II)) with these new ligands, and characterized by elemental analyses, spectrophotometric studies (IR, NMR and UV-Vis.), molar conductivity and magnetic moment determinations to enable the elucidation of the geometrical structure of the prepared metal complexes.
The cytotoxic activity for most of the newly synthesized compounds was examined in vitro against the human breast cancer cell line (MCF-7). The Schiff base ligands were found to be biologically active and their metal complexes enhanced their cytotoxic activity. Copper and silver complexes showed a remarkable smaller value of IC50 than that of the Tamoxifen which would provide a new potential antitumor drug that deserves more attention.