الفهرس 
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Abstract
The tratment for advanced cancer of head and neck,
has long been :a. major problem for otorhinolaryngologists
Its low cure rate utilizing surgery or radiation as
sLngle modalities has never been satisfactory. Then
along came the use of so called combined therapy (comb-
ined surgery and rauiotherapy ) which is also not statis-
factory enough in view of the cure rate • In recent years
a third modality has envolved, namely chemotherapy for
treatment of head and neck cancer •
Cancer trea~nent reserch began in earnest-·at the
turn of the century with three major pieces of work the
first was the development of the principles of cancer
surgery, second discovered of X-rays, third is the using
of rodent models •
Most chemotherapeutic agents appear ~o enter their
major antitumour and toxic effects by inhibiting replica-
tion of cells that undergo D.N.A. synthesis at sometimes
during their life cycle’.
Chemotherapeutic agents commonly used are (Metho-
trexate Bleomycin, Cis-platinum, Cyclophosphamide ,
Adriamycin and 5-Flurouracil, Vin b Laa tin e, Mechlore th-
amine, Procarbazine and Hydroxyurea). Factors influencing