الفهرس 
introduction
liver functionsOnly 14 pages are availabe for public view
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Abstract
In mammals, TH is necessary for growth and development of the kidney and for the maintenance of water and electrolyte homeostasis. Also TH have multiple effects on liver function including stimulation of enzymes regulating lipogenesis and lipolysis as well as oxidative processes. More over, hypothyroidism has been reported to induce mild hyperhomocysteinemia and endothelial dysfunction. So, the impact of hyperhomocysteinemia explains increase oxidative stress and alternation in some parameters of liver and kidney as cholesterol and creatinine. On the other hand, folic acid has been reported to have an0 antioxidant power against free radicals, and an alleviating role in hyperhomocysteinemia and the associated endothelial dysfunction. Also, progressive folate deficiency is suggested to develop with hypothyroidism. The present study aimed to declare the effect of low thyroid hormone status on total plasma homocysteine level and oxidative stress parameters which affect respectively on liver and kidney function. It also aimed to elucidate the role of folic acid supplementation in reducing these changes and building up the antioxidant status as a concurrent treatment with hypothyroidism and as a post-treatment after restoration of the euthyroid state. The experiment was performed on fifty male albino rats . Allthe experiments were done in compliance with the guiding principles in the care and use of laboratory animals.