الفهرس 
Tissue Doppler ImagingOnly 14 pages are availabe for public view
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Abstract
Obesity, even without comorbidities, is generally associated with cardiac events. Overt systolic and diastolic dysfunction has been described in obesity. New findings, indicating the occurrence of pre-clinical systolic and diastolic dysfunction, even in young obese patients, suggest that obese patients should be carefully monitored in order to detect incipient dysfunction.
Since traditional echocardiographic measurements of ventricular function, such as ejection fraction, fractional shortening and mitral inflow are load-dependent, the investigation of right and left ventricle subclinical dysfunction in obesity by sensitive newer echocardiographic techniques, such as tissue Doppler imaging, myocardial strain and strain rate looks like very promising. These techniques permit a quantitative assessment of both global and regional function and timing of myocardial events as well as the assessment of early changes in systolic and diastolic function.
Early detection of cardiovascular abnormalities is very important because the control of this process seems to be more effective during the initial stages of the disease.
The current study was conducted on 60 subjects were divided into two group without comorbidities, thirty subjects with BMI more than 30 representing the obese group and thirty subjects with BMI less than 30 representing the control group referred to the echocardiographic lab at Ain Shams University Hospital for echocardiographic assessment.
The candidates were subjected to the following:
1- History taking.
2- Clinical examination.
3- Laboratory examination.
4- Echocardiography (conventional echocardiography and tissue Doppler imaging): with assessment of left ventricular dimensions, left ventricular systolic and diastolic function, left ventricular mass, left ventricular mass index.
This current study concluded that obese subjects had a significant increase in LVM and LVMI when compared with non-obese subjects.
It also concluded that healthy obese subjects exhibit alterations in LV structure and function manifested by eccentric LV remodeling, decreased global LV systolic function and also regional LV function and increased left atrial dimension.
Regional left ventricular systolic function showed significant reductions in systolic myocardial velocity and deformation properties among the obese subjects in the left ventricular selected segments in this study (longitudinal fibers) without reductions noted in the posterior wall (circumferential fibers) as the reduction in longitudinal shortening in the early stage is compensated by an augmentation of circumferential shortening.
A highly significant direct relation was found in the present study between BMI versus left ventricular mass and left ventricular mass index, significant inverse relation between BMI and the peak systolic velocity of strain and strain rate.