الفهرس 
Macrovascular and Microvascular Complication of Diabetes and Mechanism of Atherogenesis In DiabetesOnly 14 pages are availabe for public view
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Abstract
The Relationship between diabetes control and
lower limb ischemia in diabetic ischemic patients
Abstract
Background
Peripheral arterial disease affects approximately 12 million approximately 20% to 30% of these patients have diabetes. Diabetes serves as a powerful risk factor for development of atherosclerosis of the large- and medium-sized muscular conduit arteries that supply the lower extremity.
Objectives
To study the relationship between diabetes control and its effect on macrovacular complications especially of lower-limb. Peripheral arterial disease diagnosed by measuring ankle brachial index in patients with documented coronary artery disease by coronary angiography.
Methods
Seventy diabetic patients with documented coronary artery disease were subjected to measure ankle brachial index by Doppler and estimation of HbA1C and lipid profile.
Results
This study showed a significant relationship between diabetes control (HbA1C), peripheral arterial disease (ABI) (p< 0.01, r= -0.920, -0.515)& LDL (p=0.04, r=0.237). Additionally, HbA1C has a significant relationship with duration of diabetes (p=0.002, r= -0.357. Also, cholesterol has a significant relationship with ABI (p= 0.01, r= -0.281). Additionally, there is a significant relationship between hypertention & severity of reduction of ABI (p=0.04). Finally, almost of patients were uncontrolled with ischemic heart disease that indicate the relationship between diabetes control & coronay artery disease.
Conclusion
We conclude that diabetic patients with angiographically documented coronary artery disease had a higher prevalence of peripheral arterial disease than other with diabetes only. The severity of peripheral arterial disease as measured by ankle brachial index increases significantly with the level of glycosylated haemoglobin.