الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
 |  | from | 197 |  |  |
| | | from | 197 | | |
Abstract
Our study was carried out in both Medical Biochemistry and Pediatric departments, Faculty of Medicine, Zagazig University. It included one hundred subjects who were divided into four groups. Group I: It included 25 normal apparently healthy female children who were free from any diseases that interfere with this study. Group(II): comprised 25 female patients with atopic bronchial asthma. Group (III): comprised 25 female patients with non atopic bronchial asthma.Group (IV): comprised 25 female patients with allergic rhinitis All groups were subjected to the following: a) Total IgE level by ELISA. b) Serum IL-13 level by ELISA. c) Analysis of IL-13 receptor alpha 1 gene polymorphism (A1398G allele) by PCR according to (Heinzmann et al., 2000). Our results showed non significant association between IL-13 Rα1 (A+1398G) gene polymorphism and the susceptability of diseases in groups II, III and IV as compared to control group. Regarding serum IgE and IL-13 concentration, they significantly increased in groups II, IV as compared to control group. Also there were a significant increase of serum IgE and IL-13 levels in groups II, IV as compared to group III and there was no statistically significant difference between group III and control group, or between group II and group IV .