الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Diabetes or hypercholesterolemia enhanced deformations of fetal skin including retarded cornification of eidermis and differentiation of hair follicles of 15,17 and 19 days fetuses SEM examination. The outline surface deformations were clarified by degeneration of granulosum layer in consistent with reduction of keratinocytes which was influenced by reduction of cornification. The other epidermal cell layers including stratum germinativum and spinosum were altered and consequently shared in massive degeneration of hair follicles. TEM explained the deterioration of cytological structures of keratinocytes with apparent reduction of keratohyaline granules contributing of stratum corneum formation as affected the germinativum and spinosum cells which contributed to differentiation of hair follicles. ultra structural observations revealed a stricking accumulation of lipid deposits underneath within the stratum granulosum of 17 days fetuses of diabetic mother beside widespread of vacuoles throughout the epidermal cell layers of both17and19days fetuses of diabetic or hypercholesterolemia mothers. A considerable reduction and disintegration of keratohyaline granules were detected manifesting the retardation of keratinized skin surface. The observed findings of accumulation of lipids within epidermal layers may attracts macrophages, leading to atherosclerotic plaque formation and increased plaque instability due to formation of foam cells and macrophage death and aggravate atherosclerotic outcomes. SDS-PAGE of skin of 15, 17 & 19 days-old fetuses of either diabetic or hypercholesterolemia mother showed decreased intensity of many of the protein bands beside missing of expressing protein bands as mentioned by dendrogram. The dendrogram illustrating the variations between bands exhibited marked reduction of protein expression mostly detected in 19 days fetuses maternally diabetic DNA fragmentation of fetuses skin. Genomic DNA fragmentation are markedly detected in 15, 17 and 19 days fetuses maternally diabetic and or hypercholesterolemia comparing with no DNA.