الفهرس 
Allergic diseasesOnly 14 pages are availabe for public view
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Abstract
Chronic urticaria is a dermatological condition characterized by monomorphous dermatosis meaning a short-lived eruption, characterized by circumscript edema of superficial dermis.[74]
This condition is associated with high morbidity and impairs patient quality of life (social impressments, work abstinence and bad scholastic achievement in children).
Detecting the etiology is always difficult, it is mainly based on careful history taking and high clinical suspicion.
The possibility of infections, infestations, physical urticaria and autoimmunity must be considered in every patient.
Genuine food allergy is allergy is a rare cause of chronic urticaria although there is increased percentage of patients showing allergy to food preservatives.
Skin test and other allergic tests may show positivity to aeroallergen, this observation make many allergists wander whether if this urticaria patients are truely sensitized to aeroallergens .Some explained this observation by the fact that many of allergy tests shows false positive results. Others explained this by the fact that many of airborne allergens come in contact with skin (contact urticaria).
In our study we aimed to evaluate the prevalence aeroallergen sensitization in patients of chronic idiopathic urticaria with no associated allergic respiratory symptoms. the patients tested positive to aeroallergen received a protocol of sublingual immunotherapy and followed.
Results:
1- The study group included 200 patients of chronic urticaria patients distributed as the following: 26 patients had etiology for urticaria (13%) including infections (5%), parasitic infestation (2%), sensitivity to aspirin and food additives (2%), sensitivity to other allergens (7.5%) and autoimmunity was diagnosed in 1 patients (0.5), the remaining 174 patients (87%) were diagnosed as chronic idiopathic urticaria.
2- Skin test positivity to inhalant allergen only was detected in 30 patients (17.2%), while in control group only 7 participants out of 200 tested positive to inhalant allergens only(3.5%)
3- The main age in the study group (30 patients) was 34 ± 9 years, while in control group (7 individuls) was 31 ± 6 years.
4- Study group has variable durations of their symptoms ranging from 2-24 monthes (mean = 8.07± 5).
5- 25 patients in study group (n=30) were sensitized to multiple inhaled allergens (83.4%), while 5 patients were mono-sensitized to inhaled allergens (16.6%) according to SPT results.
6- The most common allergens detected by SPT in the study group were mites (80%), other aeroallergens detected were MP, HD, MM 30%, 30% and 23.3 %, respectively .
7- Aeroallergen detected in control group were mite (42.8%), MP (28.5%).
8- Total IgE and was initially elevated in all study group patients (>100 IU/ml) with mean level (305 ± 208)IU/ml.
9- Specific IgE was initially elevated to allergens detected by SPT (>0.35 Ku/ml).
10- The PIT results in same patients were variably different from skin test results. The most common allergens detected by PIT were mite, milk, aspirin and HD 46.7%, 40%, 26.7% and 23%, respectively.
11- Study group recieved sublingual immunotherapy protocol for 3 monthes. Only 12 patients were able to complete the course.
12- Skin symptoms were variably improving in all the patients (n=12) using urticaria severity score (USS).
13- Both total and specific IgE to the detected aeroallergens were decreased significantly after immunotherapy.