الفهرس 
MisoprostolOnly 14 pages are availabe for public view
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Abstract
This was a study conducted to compare clinical effectiveness of low dose sublingual misoprostol versus intramuscular oxytocin for active management of 3rd stage of labor. It was performed at Ain Shams university maternity hospital in the period from May 2009 till April 2010 and it included 300 low-risk women with term pregnancy and spontaneous onset of labor. After informed consent, women were randomly divided using random number tables into three groups of 100 each, and received either (100 µg) or (200 µg) of misoprostol sublingually or 10 u of oxytocin i.m. injection after the delivery of the anterior shoulder of the baby. Every patient of the studied women was subjected to hemoglobin and hematocrit levels before delivery and 24 hours post-partum. The main outcome measures were the duration of the third stage of labor, amount of blood loss, need for additional oxytocic drugs, change in hemoglobin and hematocrit levels, side-effects and complications.
from the results of this study there was no statistically significant difference between the study groups as regard demographic characteristics (maternal age, gestational age, and birth weight). The mean third stage duration for the study groups was 4.2, 5.5, and 6.5 minutes for group I (Oxytocin), group II (Misoprostol 2oo µg), and group III (Misoprostol 100 µg) respectively. Post-partum hemorrhage (≥ 500 mL blood loss) did not occur in any of the women, and the mean amount of blood loss for the study groups was 168, 195, and 234 ml for group I, group II, and group III respectively. Additional oxytocics were used in 3 ,5 and 5 % cases in group I, II and III respectively. The mean percent change (reduction) of Hb level for the study groups was 4.7, 4.9, and 5.5 % for group I, group II , and group III respectively. The mean percent change (reduction) of HCT level for the study groups was 4.9, 4.8, and 5.5 % for group I, group II, and group III respectively. And group II had the highest percentage of adverse effects (6% for nausea and 5 % for fever) compared to the other two groups with statistically significant difference in between.