الفهرس 
ChemistryOnly 14 pages are availabe for public view
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Abstract
The virtual screening studies that have been achieved through insilico
approachs indicated that the designed molecules (IVa-f, Va)
would be considered as active hits as PPARγ agonists.
Unfortunately, the model for the in-vitro or in-vivo screening for
the PPARγ agonistic and insulin sensitizing activities were not
available for us. But, since such molecular modeling studies were
performed using caliberated modules and their results were
statistically validated , so these in-silico studies were considered as
valid tools for predicting the biological activity of the test
molecules (IVa-f, Va) with high confidence.
Accordingly, these active hit molecules (IVa-f, Va), were
synthesized and their structures were confirmed in order to be
available, in the future, for in-vivo and in-vitro evaluation as
antidiabetic agents .