الفهرس 
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Abstract
In the present study, we have evaluated the prophylactic activities of
silymarin against liver cells damage due carcinogenic effect of DENA in
rats at molecular level, through the evaluation of its effects on the
expression of rnRNA of SOD, CAT, p53, and COX-2.
Sixty four male Albino rats were used in the study. Their Wight
ranged from 160-180 grams. The rats were divided into 6 groups: Control
group, DENA Group (rats injected with a single i.p. dose of DENA
(200mg/kg), two weeks later they were injected i.p. with CC14 (2 mL/kg)
three times ( a dose / week) to induce HCC), two pretreated groups with
40 and 80 mg/kg bw SMN, and two post-treated groups with 40 and 80
mg/kg bw SMN. ALT, AST and total & direct bilirubin were investigated
in serum. SOD and CAT were investigated in hepatic tissues. Also, the
gene expression of SOD, CAT, p53, and Cox-2 was determined in hepatic
tissues.
After statistical analysis our results referred to the following:
~ Serum ALT & AST activities and total & direct Bilirubin
levels:
DENA group revealed significant increase in the level of total& direct
bilirubin and in the activities of ALT & AST but silymarin -treated rats
revealed improvement in these liver functions.
~ Superoxide dismutase and Catalase activities in Hepatic
homogenate: