الفهرس 
Review of literatureOnly 14 pages are availabe for public view
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Abstract
Hepatitis C infection represents a major health problem especially in Egypt.
Chronic hepatitis C virus infection seems to share autoimmune pathogenic
mechanism with other autoimmune disease, as it responds to monoclonal antibody
(mAb) treatment (i.e. rituximab). Rituximab is the only anti CD20 available
antibody for treatment of several diseases (e.g. lymphoma, RA and arthiritc
manifestations of HCV infection) confirming a role of B-cells in pathogenesis and
treatment of such diseases. However, limited studies aimed to measure expression of CD20 in peripheral blood.
Hepatitis C infection represents a major health problem especially in Egypt.
Chronic hepatitis C virus infection seems to share autoimmune pathogenic
mechanism with other autoimmune disease, as it responds to monoclonal antibody
(mAb) treatment (i.e. rituximab). Rituximab is the only anti CD20 available
antibody for treatment of several diseases (e.g. lymphoma, RA and arthiritc
manifestations of HCV infection) confirming a role of B-cells in pathogenesis and
treatment of such diseases. However, limited studies aimed to measure expression
of CD20 in peripheral blood.
The results of the present study revealed thatIncreased levels of CD20 and CD27 in study in comparison to controlgroup and CD27 is correlated well with other studied parameters than CD20