الفهرس 
Pathogenesis of hemorrhagic.Only 14 pages are availabe for public view
 |  | from | 206 |  |  |
| | | from | 206 | | |
Abstract
Objective: This study aimed to investigate the predictive and risk factors of development of hemorrhagic transformation (HT). Methods: Three hundred twenty four consecutive patients admitted with acute cerebral infarction were recruited and submitted to clinical evaluation including National institute of health stroke scale (NIHSS), laboratory investigations, baseline computed tomography (CT) scan, magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA), follow up CT scan within 5-8 days from onset. Results: Patients with HT had higher NIHSS score, larger volume of infarction, more prevalent early ischemic changes in baseline CT, microbleeds and significant intracarnia arterial stenosis in MRI. Also, tended to higher levels of random blood sugar (RBS), lower platelets count, higher total leukocyte count (TLC), higher values of international normalized ratio (INR), and lower cholesterol levels. AF and cardioembolic stroke were more common among patients who developed HT. Conclusion: Cardioembolic stroke (P=0.0001), stroke attributable to large artery atherosclerosis (P=0.015), AF (P=0.008), large infarction (P=0.0001), microbleeds (P=0.0001), high RBS (P=0.0001) and INR (P=0.021) on admission are independent predictors of hemorrhagic transformation.