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Abstract The early diastolic velocity pattern in the normal left ventricular (LV) wall segments has been described as a high diastolic velocity corresponding to the rapid filling phase and low uniphasic or biphasic velocities in the isovolumic relaxation (IVR) period (Tavil et al., 2007). This normal relaxation pattern can be disturbed by persistent contraction after the aortic valve closure in ischemic myocardium, which has been termed as post systolic shortening (PSS) (Voigt et al., 2003). In the myocardial segments with normal pattern of early diastolic velocity or PSS, the early diastolic peak velocity always appears in the rapid filling phase (D’Andrea et al., 2001). However, in clinical practice, some segments relax with the early diastolic peak velocity lying in the IVR period instead of the rapid filling phase (the PVIVR)(Zhang et al., 2007). Tissue Doppler imaging (TDI) is a useful echocardiographic method that derives measurements of contraction and relaxation velocities directly from the myocardium (Edvardsen et al., 2002). Tissue Doppler imaging was used to investigate the segments of which early diastolic peak velocity lies in the IVR period and to further characterize these segments (Zhang et al., 2007). However, the association between the presence of early diastolic peak velocity in the IVR period (PVIVR) or PSS by TDI and the presence of significant CAD by coronary angiography has not been elucidated. introduction&aim of the work 2 Aim of the work We aimed in this study to investigate the association between resting segmental isovolumic relaxation velocities (either the PSS or the PVIVR) detected by tissue Doppler imaging and the presence of significant coronary artery stenosis by coronary angiography. |