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Abstract This study was carried out to revise the prevalence of nutrition disorders and abnormal laboratory findings like fasting blood glucose levels, lipid profile (total cholesterol; TC, and triglycerides; TG), lipoprotein patterns (low density lipoprotein LDL-c, and high density lipoprotein; HDL-c), and fasting plasma insulin among obese children and adolescents, to test the presence of insulin resistance syndrome among those with other disorders to clarify the association between obesity and physical inactivity and dietary practices , and to assess HOMA R as screening and monitoring test for insulin resistance syndrome among obese children and adolescents 100 obese children and adolescents (age from 6 - 18 years, mean age 11.610± 3.516 year) were assessed. Two main types of data were reported (medical and dietary) to cover topics related to obesity, diabetes, hypertension and physical activity. Weight height, waist and BMI were measured and referred to their corresponding international reference values properly matched for age and sex. A Fasting blood sample was drawn to assess lipid (total cholesterol; TC, and triglycerides; TG), lipoprotein patterns (low density lipoprotein; LDL-c, and high density lipoprotein; HDL-c), fasting blood glucose and fasting plasma insulin. HOMA-R was calculated using a computer-derived equation to assess body response to insulin among target br>Results Main results of our study showed that 68 %from total sample had HOMA-IR > 2.5 this mean that around tow-third from total sample were resistant to insulin with higher prevalence among females than males and higher prevalence among adolescents than children. This study also showed significant relation between insulin resistance syndrome and dietary pattern of the studied sample. Main results of our life style intervention showed very highly significant changes between pre and postanthropometric measurements for sub sample (n=32) from the total studied cases0.000 for both Weight (Kg), BMI)Kg/m2) and Waist Circumference (cm). These changes also lead to laboratory improvement in insulin resistance syndromeindicators like fasting blood glucose levels, glycated hemoglobin HbA1c %, lipid profile (total cholesterol; TC, and triglycerides; TG), lipoprotein patterns (low density lipoproteinLDL-c, and high density lipoprotein; HDL-c), and fasting plasma insulin among obese children and adolescents whomincluded with our intervention. This means that the healthy life style intervention (by encouraging daily physical activities, exercises with balanced low caloric diet and planning to reduce about 10% from body weight) is very useful for preventing or reducing insulin resistance syndrome and its complications among obese children and adolescents. Summary -118- Diet and lifestyle modifications are the first line of treatment in dealing with insulin resistance syndrome as the main recommendations are to balance caloric intake and physical activity to achieve and maintain a healthy body weight as possible as. |