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العنوان
Protective Role Of Alpha Lipoic Acid Against Disorders Induced By Gamma Radiation /
المؤلف
El Zeem, Khalid Nady Mohammed.
هيئة الاعداد
باحث / Khalid Nady Mohammed Abd El Azeem
مشرف / Wafaa M. Zahran
مشرف / Soad Abdel Salam
مشرف / Mahmud H. Ayoub
الموضوع
Gamma Rays - Influence physiological.
تاريخ النشر
2011.
عدد الصفحات
220 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
علم الحيوان والطب البيطري
تاريخ الإجازة
1/1/2011
مكان الإجازة
جامعة المنيا - كلية العلوم - Department of Zoology
الفهرس
Only 14 pages are availabe for public view

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from 258

Abstract

Ionizing radiation interacts with living cells, causing a variety of biochemical changes depending on exposed and absorbed doses, duration of exposure, interval after exposure and susceptibility of tissues to ionizing radiation. So, it may increase the oxidative stress and damage of body organs. Alpha-lipoic acid (ALA-also known as thioctic acid) appears to be readily absorbed from an oral dose and converts easily to its reduced form, dihydrolipoic acid (DHLA), in many tissues of the body. ALA can neutralize free radicals in both fatty and watery regions of cells.
The present study has been designed to evaluate the possible efficiency of ALA as antioxidant and radio-protector against radiation induced oxidative stress in different organs (liver, kidney and heart) in rats through estimation of the activity of markers of serum liver, kidney and heart function, in addition to the histopathological differentiation of these organs by light and electron microscope.