الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 119 |  |  |
| | | from | 119 | | |
Abstract
Objective: to compare gonadotropine /antagonist protocol with and without Letrozole for controlled ovarian hyperstimulation for poor responder cases undergoing ICSI.
Design: Prospective randomized case control study.
Sitting: Mansoura Fertility Care unit, Mansoura University hospital, Mansoura, Egypt.
Intervention: Controlled ovarian hyperstimulation/ICSI
Outcome: The primary outcome is to measure duration of stimulation, total dose of gonadotropins, serum E2 level and endometrial thickness on day of HCG administration. The number and degree of maturation of retrieved oocytes, fertilization rate and number and grade of the developed embryos were evaluated. Secondary outcome includs implantation rate and clinical pregnancy rate .
Results: Duration of stimulation was shorter in group A (10.2± 1.5 days) compared to (11.5± 1.9days) in group B, total dose of gonadotropins was lower in group A (2602±433) in contrast to (2752±515IU) in group B, endometrial thickness was thicker in group B (9±2.2mm) compared to (7.8±2.2 mm) in group A, but no significant difference was detected between the two groups apart from mean duration of stimulation.
Conclusions: Letrozole as an adjuvant to gonadotropins seems to reduce stimulation period and total gonadotropins units used.