الفهرس 
Introduction & Aim Of The WorkOnly 14 pages are availabe for public view
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Abstract
The present study was carried upon 70 diabetic patients (group 1)
and fifteen apparently healthy children (group 11).
All the groups were subjected to:
1-History taking.
2-Clinical examination.
3-Laboratory investigations which included:
- Random blood sugar.
- GFR
- Serum cystatin C.
- Renal function tests.
By this study we found that there were statistical significant
differences between the two studied groups as regard serum cystatin C
level. Through the comparison between the two groups we found that
there were significant statistical differences between the two groups
which support that cystatin C is a good endogenous marker for GFR. By
studying the sensitivity of cystatin C and creatinine we found that
cystatin C is more sensitive marker than serum creatinine for small
changes in GFR. Moreover we found that there were no significant
statistical correlations between the serum cystatin C level and the
albumin to Creatinine ratio in the studied groups.
In conclusion, Cystatin C seems to be a promising, new and easily
measurable marker for prompt detection of early kidney failure. Recently
it was suggested that serum creatinine is a poor marker of GFR, while
serum cystatin C concentration provides a better indication of changes in
GFR than does serum creatinine. Although multiple factors in
addition to renal function may influence cystatin C, our study provides
convincing evidence that cystatin C may be more useful for detecting
early renal impairment in type- 1 diabetic patients than are creatinine and
the commonly employed creatinine- derived formulas.
Individuals with moderate or mildly decreased renal function are at
increased risk for chronic kidney disease and cardiovascular disease.
Adverse outcomes of renal failure can be prevented or delayed through
early detection and treatment. Therefore the routine estimation of GFR is
strongly recommended for patients at high risk for kidney failure and
cardiovascular disease such as diabetic patients.
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