الفهرس 
PEROXISOMESOnly 14 pages are availabe for public view
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Abstract
Peroxisomes are intra cellular, spherical, small ,membrane-enclosed organelles ,that are 0.2 - 1.7mm and bound by a single membrane. They contain enzymes involved in a variety of metabolic reactions including several aspects of energy metabolism.
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The main function of peroxisomes is the break down of the very long chain fatty acid through beta oxidation. They play an important role in the cell metabolism of lipids, hormones and regulation of cell proliferation and differentiation which in turn modulate inflammatory responses.Peroxisomal receptors are nuclear hormone receptors that present as three isotypes PPAR α ,PPAR β/δ, PPAR γ .On their activation or inhibition by either natural or synthetic agonist and antagonist they exert their action in inflammatory skin disorders ;ie acne vulgaris since activators of PPARs in particular of the δ subset might have beneficial effects on acne vulgaris by inhibiting the release of lipids in the context of sebocyte apoptosis, In atopic dermatitis PPARs might exert a beneficial role through the combination of it’s properties in immune responses and epidermal differentiation and regulation of epidermal protein and lipid production. In contact dermatitis the anti-inflammatory properties of PPAR α agonists, coupled with their anti-proliferative and pro-differentiating effects, suggest that they could be beneficial for it’s treatment ,Also PPARγ activation has an inhibitory effect on psoriatic skin lesions since it was found to suppress proliferation and induce differentiation of psoriatic human keratinocytes, In skin malignancies as malignant melanoma, squamous cell carcinoma, actinic keratosis studies have shown that PPARα and PPARγ activators induce differentiation and inhibit proliferation in normal and hyperproliferating mouse epidermis and regulate apoptosis ,use of PPARα activators have chemoprophylactic properties in the prevention of early stages of cancer or it’s precursor lesions .