الفهرس 
Liver FunctionsOnly 14 pages are availabe for public view
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Abstract
The present study was conducted on thirty one (31) patients with stigmata of decompensated chronic liver disease based on clinical, laboratory and radiological data, admitted to Ain Shams University Hospitals, Tropical Medicine department or attending outpatient clinics during the period from September 2009 to March 2010.
In addition, twenty healthy (20) control males were selected as a control group. They had the same age range and environmental factors as recruited patients, with no past history of any chronic disease, normal liver functions and free clinical examination.
We studied the levels of free & total testosterone, estrogen and sex hormone binding globulin (SHBG) and tried to correlate them with clinical manifestations in recruited patients. The statistically analysed results showed that the free and total testosterone levels were significantly decreased in decompensated chronic liver disease patients (cases) when compared to control group.
On the other hand, estradiol (E2) level showed a significant increase in decompensated chronic liver disease patients (cases)when compared to control group.
Also, we found that SHBG showed a significant increase in decompensated chronic liver disease when compared to control group and there was a positive correlation between SHBG & E2 levels.
There was a significant positive correlation between serum albumin and free, total testosterone levels.
In addition to this, there was an increase in serum levels of E2 in patients with signs of feminization as: gynecomastia, loss of body hair and spider navai.
As regards Free Androgen Index (FAI), there was a significant decrease of its value in studied patients when compared to control group. Also, there was an increase in E2/free T ratio in our cases when compared to control group, which indicates hyperestrogenism in our cases.
There was a significant lower level of free, total testosterone and significant higher levels of E2 and SHBG in patients receiving spironolactone than in those who were not receiving this medication.