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Abstract FMF is almost always restricted to Turks, Armenians, Arabs, and non-Ashkenazi Jews. It is quite a rare disease in the rest of the world, although patients with FMF have been reported in European countries such as France, Germany, Italy, and Spain, as well as in the US and Australia. FMF is a disorder characterized by sporadic, paroxysmal attacks of fever and serosal inflammation. The gene responsible for FMF was mapped onto the short arm of chromosome 16. The most severe ,important, long-term complication is amyloidosis type AA. Among Sephardi Jews and Turks, FMF represents the main cause o f amyloidosis type AA.results from the deposition of amyloid A protein |