الفهرس 
drug abuse
resultsOnly 14 pages are availabe for public view
 |  | from | 192 |  |  |
| | | from | 192 | | |
Abstract
Prescription drug abuse increased dramatically in the past decade. Among the most extensively abused drugs are Tramadol and Clonazepam. Tramadol is an atypical opioid widely used as a br>centrally acting analgesic and has been reported to be one of the most br>popular drugs of abuse. Clonazepam is a high potencybenzodiazepine, with a significant abuse potential. Mitochondrial dysfunction has been shown to be a pharmacotoxicological response to a variety of currently marketed drugs. Considering the complexityof mitochondria, it is not surprising that they are often the target ofdrug-induced toxicity. Thus, this study aims to evaluate the effect of tramado I, clonazepam or their combination on mitochondrial electron transport chain complexes whether at therapeutic or at progressively increasing doses. 70 healthy male rats aging ~3 months and weighing 180-220 g were divided according to the drug intake regimen into 7 groups namely; Control, Tramadol therapeutic, Clonazepam therapeutic, Combination therapeutic, Tramadol abuse, Clo nazepam abuse and Combination abuse group. After 30 days of exposure to different drug regimens, rats were weighed and then sacrificed and brain mitochondrial electron transport chain complexes (1, Il, III & IV) were determined. Histopathologic examinations were also performed on brain tissues. Serum ALT, AST, ALP, LDH activities, BUN and creatinine levels were also measured. Results showed that groups that received tramadol therapeutic and abuse) suffered from weight loss .