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Abstract The rate of tumor recurrence of superficial bladder cancer is 50–80% in the first 2 years after diagnosis; progression to invasive disease accounts for 15–23% of recurrences. The detection rate of a further UUT-UCC is 2–10%. Conventional cystoscopy and urine cytology is the standard method for detection and follows up of urothelial bladder tumors. However, conventional cystoscopy has some disadvantages in that it is an invasive, expensive, and time-consuming technique. So, new noninvasive methods for the diagnosis and surveillance of UCCs are therefore urgently required to replace cystoscopy. In this study we tried to discuss the role of modern technology for early detection of urothelial tumors recurrence. These new diagnostic modalities could be summarized in three main categories: cancer biomarkers, new imaging methods, and modern optical methods. The FDA (food and drug agency) in the USA has already accepted urinary tests for monitoring patients with bladder cancer, including: Nuclear matrix protein 22 (NMP22), Bladder tumor antigen (BTA), UroVysion (fluorescence in situ hybridization - FISH) test, ImmunoCyt, and Hyaluronic acid (HA). |