الفهرس 
COAGULATION OVERVIEWOnly 14 pages are availabe for public view
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Abstract
Disorders of hemostasis and thrombosis are often caused by sepsis-related disseminated intra vascular coagulation (DIC), the coagulopathy of severe liver dysfunction , massive transfusion ,anticoagulant overdose, primary fibrinolysis, Thrombotic Thrombocytopenic purpura (TTP), Hemolytic uremic syndrome(HUS) and vitamin K deficiency in the differential diagnosis.
These disorders are frequently encountered in the ICU setting. Understanding the relevance of laboratory findings is essential in providing appropriate therapy. Various blood products and hemostatic agents are available to assist in the control of bleeding and several different classes of anticoagulants are now available for use. Appropriate use of these agents maximizes therapeutic effect while minimizing complications. Use of fresh frozen plasma, cryoprecipitate and other hemostatic agents should generally be reserved for those who have active bleeding, those undergoing invasive procedures and those at high risk for bleeding because of their underlying diagnosis or because of associated hematologic derangements.
Thrombocytopenia is common in critically ill patients and may be associated with adverse outcomes. A systematic evaluation of clinical and laboratory findings is necessary to ascertain the cause of the thrombocytopenia and to determine the correct therapy. Recognition of heparin-induced thrombocytopenia (HIT) is particularly important, given the risk of thrombosis associated with this condition. Prompt cessation of all heparin products is required, and anticoagulation with a direct thrombin inhibitor is recommended if HIT is strongly suspected.