الفهرس 
POLYCYSTIC OVARIAN DISEASEOnly 14 pages are availabe for public view
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Abstract
BODY FAT QUANTITY AND DISTRIBUTION AMONG EGYPTIAN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME
Submitted for Partial Fulfillment of the Master degree in Obstetrics and Gynecology
By Doaa Mohamed Ali
M.B, B.Ch(Kasr Al Ainy, 2002)
Supervised by
Prof:Osama Saleh El-Kady
Prof: Tarek Mohamed Tamara
Assistant prof : Ahmed Khairy Makled
ABSTRACT
Polycystic ovary syndrome is one of the most common endocrine disorders in women of the reproductive age. The overall prevalence among women in this age group is between 4% and 10%. It is commonly diagnosed in young women with anovulatory infertility, oligomenorrhea or hyperandrogenic problems such as hirsutism and acne. Although associated with obesity, the syndrome is also frequently seen in normal body weight.
Hyperandrogenaemia (originating from a predominantly ovarian source) is the most consistent endocrine feature in women with PCOS and is likely to play a key role in the etiology of the condition. Indeed, non-PCOS conditions associated with hyperandrogenaemia in women (including congenital adrenal hyperplasia) often mimic PCOS. It is also clear that adiposity play a crucial role in maintaining and presumably in generating PCOS. Evidence for this includes the often dramatic improvement in menstrual irregularity in response to weight reduction in women with PCOS.
While most attention has been paid to the management of the presenting complaint (infertility, hirsutism, etc.), it has become clear that the polycystic ovary phenotype is linked to a number of metabolic disturbance, including type-2 (non-insulin –dependent) diabetes.
Women with PCOS are frequently found to have insulin resistance as well as the effects of genetic ethnicity, obesity and life style factor, high free testosterone, found in obese more than non obese women who have PCOS. Our study aimed at determining and assessing the hormonal profile in women with PCOS in relation to body mass index. This was done to detect the pattern of body fat distribution present, which gives a clear idea of the women at risk of developing the long-term health consequences of this syndrome. Therefore, in this study, we examined the pattern of hormonal profile, insulin resistance and distribution of body fat mass in 100 patients with PCOS in reproductive age. The subjects in this study were categorized according to the BMI into obese (BMI ≥ 28 Kg/m2) and non-obese (BMI < 28 Kg/m2). All cases were diagnosed as having PCOS according to the international known diagnostic criteria for this condition. Both gave a complete medical history and were through examined, and their blood samples were examined for hormonal profiles.
the results o this study showed that patient with PCOS with BMI ≥ 28 Kg/m2 showed more hormonal disturbance, tendency to diabetes and more insulin resistance than patient with PCOS and BMI < 28 Kg/m2. These women with PCOS constitute the largest group of women at risk for the development of diabetes. Emphasis should be applied to inform health care providers and professionals and public about the need to identify these women.