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Abstract Results and Conclusions: Thrombocytopenia is the second most common hematologic abnormality during pregnancy and is usually a benign condition. Some patients, however, will have chronic medical disorders or pregnancy-induced conditions that require further evaluation and therapy. Even with its wide differential diagnosis, the cause of thrombocytopenia during pregnancy can usually be determined with a thorough history, physical examination, and directed laboratory studies. The challenge to the clinician is to weigh the risks of maternal and fetal bleeding complications against the benefits of diagnostic tests and interventions. Recommendation: There are a large number of causes of thrombocytopenia in pregnancy. By far the most common causes are mild, but awareness of the complex disorders in which thrombocytopenia occurs is essential to ensure prompt diagnosis and referral into a centre with expertise in these rare conditions, to optimize outcome for mother and baby. |