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Abstract Neonates with perinatal asphyxia have significantly higher cord blood cTnI & CK-MB levels compared to healthy non-asphyxiated ones at birth, cTnI is more reliable than CK-MB concentrations in detecting ischemic myocardial damage representing an early diagnostic marker, that can help in early intervention to prevent or even limit dangerous and bad sequelae of perinatal asphyxia. The assessment of myocardial dysfunction by serum cTnI level in the early neonatal period is likely to be of great importance in predicting morbidity of HIE, and appears to provide significant data in the clinical approach. In contrast to CK-MB increased cord blood cTnI in neonates with HIE has a highly significant relation to an increase in Sarnat staging of HIE, representing an early predictor for the severity of hypoxic-ischemic brain insult in newborns with perinatal asphyxia. |