الفهرس 
Introduction and Aim Of The WorkOnly 14 pages are availabe for public view
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Abstract
The PCOS is the most common endocrine disorder affecting women with e”alence rate was reported to be 3-7% in the general population and as high as ;~% in the infertile population
This prospective comparative study was performed in the endoscopy unit .f the Obstetrics and Gynecology department in Suzan Moubark university ospital. One hundred and twenty women overweight primary infertile movulatory CC-resistant women with PCOS were enrolled during the period from December 2006 to May 2009.
The aim of this study was to compare the effectiveness ofLOD compared with metformin administration in the treatment of cc-resistant women with PCO.
The subjects were randomly allocated into two treatment groups of 60 \Omen each (groups I and II):
All subjects underwent laparoscopy. Specifically, diagnostic laparoscopies ”ere performed in group 1. Only in group II the LOD followed the diagnostic ~rocedure For the duration of the study, each patient was blinded with regard to JJe surgical treatment performed
At hospital discharge, group I was treated with metformin c10ridrate at a ~osage of 850 mg twice daily, whereas group II received multivitamins (two ~blets/day orally). The patients were instructed to take the tablets with the meals. The duration of treatment was 6 months. For the entire period of study.
There was no statistical difference between the two groups as regarding !ge, duration of infertility, body weight and BMI .
---------.(summ~ry and Conclusion)
Our results confirm that either LOD or metformin administration are milarly effective in inducIng regular menstrual cycles in a high percentage of o\ulatory pcos women. There was no significant differences in the number of Jtients with regular cycles after treatment when compared to their number fore treatment in both groups (60% versus 6.2%in group I and 63.3% versus ;.6% in group II) (p <0.05)
There was a significant increase in the frequency of ovulatory cycles after eatment when compared to its incidence before treatment 43.3% versus 6.7% group I and 40% versus 10% in group II.
Moreover, our results show no significant difference between the two .oups in pregnancy rate ( 18.4% in group I versus 23.3%in group II). In the resent study no cases of abortion were noticed in both groups.None of the omen had multiple pregnancy.
Regarding the changes in sex hormones in either metformin or LOD .oups, there was signilicant reduction in LH level and LH/FSH ratio and free mdrogen index in both groups after treatment (p<0.05 for each), while there was o significant difference in fasting blood glucose and FSH level. Regarding the hanges in fasting insulin in both groups after treatment there was a significant oouction in the mean fasting insulin in metformin group (p<0.05) compared ~th the LOD group.
As regarding the assessment of ovarian reserve, There was significant . tistical reduction of antral follicle count, summed ovarian volume and serum Jhibin level in the group treated with LOD in comparison to the group treated ith metformin .