الفهرس 
DEFINITION AND DIAGNOSIS OF PCOSOnly 14 pages are availabe for public view
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Abstract
The Polycystic Ovary Syndrome (PCOS) is a heterogeneous disorder, whose
principal features include androgen excess, ovulatory dysfunction, and/or
polycystic ovaries, and is recognized as one of the most common
endocrine/metabolic disorders of women. The pathophysiology of PCOS
appears to be multifactorial and polygenic. Current evidence suggests that
insulin resistance is an important pathophysiological feature of the polycystic
ovary syndrome (PCOS). An important implication of insulin resistance in
PCOS is that insulin-sensitizing agents are a useful therapeutic approach in
this disorder, as documented by multiple clinical trials.
Clomiphene citrate (CC) is currently the first-line therapeutic modality for
women with infertility and PCOS. Overall, approximately 80% of all patients
receiving clomiphene ovulate and 40% (one-half of those ovulating)
conceive. Data suggest that decreased insulin sensitivity, hyperandrogenemia,
and obesity, all associated with PCOS, are prominent factors involved in
reducing the probability that the ovaries will respond to clomiphene.
Key Words:
Definition and Diagnosis of PCOS, Insulin Resistance and PCOS,
Clinical Pharmacology, the Role of Insulin Sensitizers in PCOS.