الفهرس 
ContentsOnly 14 pages are availabe for public view
 |  | from | 209 |  |  |
| | | from | 209 | | |
Abstract
Several studies have provided evidences for the structural and functional
conservation of RAD_6 proteins among eukaryotes. The high degree of structural
homology (69% identity) shown in the primary sequence of the human ubiquitin
carrier protein E2 (Mr = 17000) and the protein encoded by the yeast DNA
repair gene RDA6 Prompted us to investigate whether such human RAD6
homolog can functionally substitute for the Saccharomyces cerevisiae RAD6
gene in its DNA repair function. In order to evaluate this possibility, we
examined whether the human - encoded protein can provided function(s)
necessary to rescue the yeast DNA - repair deficient rad6 deletion strain YW062
by complementation.