الفهرس 
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Abstract
In this study we aimed to study of pre-prandial plasma ghrelin concentration in children with type-l diabetes mellitus and the relationship between plasma ghrelin level with some clinical and laboratory parameters. Our study included 66 patients with type-l diabetes mellitus classified into three groups ”newly diagnosed diabetic group included 22 patients”, ”good glycemic controlled diabetic group included 22 patients with regular administration of insulin therapy” and ”poor glycemic controlled diabetic group included 22 patients”. In addition, 22 apparently healthy children were included in a ”4th group” and served as controls.
We excluded from the study children with diabetic ketoacidosis, obese diabetic patients, transient hyperglycemia with active concurrent illness and diabetes associated with other medical conditions such as cystic fibrosis or associated hormonal abnormalities.
All children included in the study were subjected to clinical history taking, complete examination, anthropometric measurements as well as laboratory investigations including fasting and two hours post-prandial blood glucose, fasting plasma ghrelin, HbAle, liver function tests, renal function tests, serum triglyceride and cholesterol.
OUf study showed:
• Significant statistical differences regarding weight, weight on centile, BMI and BM! on, centile being decreased in newly diagnosed and poor controlled diabetic patients when compared with controls.
• Significant statistical differepces regarding FBG, 2 hour posttprandial glucose, HbAlc, serum cholesterol and triglycerides being elevated in newly diagnosed and poor controlled diabetic patients when compared to controls.
• Significant statistical differences regarding pre-prandial plasma levels of ghrelin being elevated in newly diagnosed and poor controlled diabetic patients when compared to controls.
• Pre-prandial plasma ghrelin levels were significantly decreased in good glycemic controlled diabetic patients when compared to poor glycemic controlled and newly diagnosed patients.
• Significant negative correlation was found between pre-prandial plasma ghrelin concentrations and each of the following: weight, weight on centile, BMI, and BMI on centile in all diabetic groups.
• Significant negative correlation was found between plasma ghrelin concentrations and each of FBG and 2 hour post prandial glucose in all diabetic groups.
• Multiple regression analysis revealed that the most important factor affecting ghrelin concentration was FBG followed by 2h post-
”,
prandial glucose, weight, BMI, while the least important factor was
the sex.