الفهرس 
Chronic inflammationOnly 14 pages are availabe for public view
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Abstract
Chronic inflammation is a hallmark of many human diseases including cardiovascular diseases, inflammatory and auto immune disorders, and cancers. Chronic inflammation often results in excess fibrosis and tissue remodeling, which interfere with tissue function. NSAIDs as selective and nonselective COX inhibitors are used mainly in the treatment of inflammatory diseases. Also, NSAIDs have also been proven to possess significant anti-proliferative potential in tumors. The purpose of this study was to investigate the molecular mechanisms of NSAIDs in controlling chronic inflammation, regarding the gene expression of PPARy1, PPARu and NAG-I. The role of some apoptotic and angiogenic mediators was also examined.