الفهرس 
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Abstract
Exposure to microorganisms and their derived products triggers a rapid and coordinated sequence of host reactions resulting in recruitment of leukocytes into areas of inflammation or sites of microbial invasion . The regulation and trafficking of leukocytes into specific body tissues are principally controlled by chemoattractant cytokines or chemokines .
Up-regulation (or down-regulation) of these mediators occurs very early in the inflammatory process, and, thus, an increase (or decrease) in circulating levels of these compounds can potentially be used as an early indicator or marker of systemic neonatal sepsis.
The aim of the study is to assess the diagnostic and prognostic value of interferon gamma inducible protein 10 in cases of neonatal sepsis.
We have recruited 86 neonates from Ain Shams University hospital from the period between 10/2010 till 4/2011
They were divided into 2 groups:
Group 1: Neonates with neonatal sepsis admitted to the neonatal intensive care unit in Ain Shams University hospital (50 patients).
Group 2: healthy neonates as a control group(36 patients).
Sepsis was diagnosed by clinical picture including (Thermal instability, respiratory dysfunction, cardiac dysfunction, perfusion abnormality, and altered mental status) and calculations of sepsis score according to Rodwell et al., (1993), and by lab findings including (CBC, IT ratio, blood culture, CRP, liver and kidney function).
All the patients were subjected to the following:
1. Complete blood count with differential count.
2. Immature neutrophils/total leucocytic count ratio(paients having I/T ratio more than 0.2 are considered cases.)
3. Blood culture (positive blood culture patients were considered cases.)
4. Liver & kidney function
5.CRP(CRP more than 6 is considered a case).
6. Calculation of sepsis score according to hematological scoring system for early diagnosis of neonatal sepsis (Rodwell et al., 1993) any patient having sepsis score of 3 or more is considered a case.
7. Plasma level of interferon gamma inducible protein 10.
The results were statistically analyzed applying the proper test.
This study revealed the following results:
• The studied cases had higher IP-10compared to controls statistically highly significant difference.
• IP-10 and sepsis were higher among died cases compared to alive with statistically highly significant difference in between, and higher with culture positive than culture negative patients.
• As regard blood culture died cases had higher frequency of different organisms in growth while alive had higher no growth frequency with statistically highly significant difference.
• IP-10 was positively correlated with total WBCs count, neutrophilic count, CRP, sepsis score using the hematological scoring system, and blood with significant correlation.
• According to our work, at 85pg/ml IP-10 can predict neonatal sepsis with sensitivity of 98% and specificity of 81%, while at 300pg/ml it can predict poor prognosis (death).