الفهرس 
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Abstract
This study was designed to provide comprehensive knowledge on histopathological alterations during the progress of the disease in liver, spleen, kidneys, lungs, heart, brain and testes of the mice infected with T. evansi, detecting the distribution of trypanosomal antigen in various tissues by using immunohistochemical technique, for this purpose eighty mice were infected with 104 Trypanosoma evansi by I/P injection. Tissue samples (liver, spleen, kidneys, lungs, heart, brain and testes) were collected from mice scarified at 3, 5, 7, 10, 12, 15, 17, 22 day post inoculation for histopathological and immunohistochemical examination. Gross post-mortem examination revealed enlargement of spleen, congestion of liver. Tissue sections revealed presence of numerous trypanosomes in blood vessels of liver, spleen, kidneys, lung, heart, brain and testes. Microscopically, liver revealed lesions varying from vacuolar degeneration, coagulative necrosis along with congestion and haemorrhages. Spleen showed extensive hemorrhages in red pulp area, extrameduallary hematopoiesis and lymphoidal necrosis. Lungs revealed oedema, congestion and mild inflammatory changes. Heart revealed mild degenerative changes along with interstitial oedema. Brain revealed mild degenerative changes along with congestion of meningeal blood vessels. Testes revealed severe testicular degeneration. All changes were consistent with trypanosome infection and were confirmed by presence of trypanosomes in most of the tissue by immunohistochemical technique.