الفهرس 
InterductionOnly 14 pages are availabe for public view
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Abstract
BACKGROUND: Intrauterine insemination (IUI) combined with controlled
ovarian hyperstimulation (COH) has been demonstrated to be an effective form
of treatment for subfertile couples.
OBJECTIVE: To determine the optimal timing of IUI in relation to hCG
administration with different protocols of induction ovulation.
DESIGN: Prospective randomized study.
SETTING: Infertility Clinic, Department of Obstetrics and Gynecology-Cairo
University Hospitals-Kasr El Aini.
PATIENTS and METHODS: Forty-five patients with mild male factor and
unexplained infertility. After COH with clomiphene citrate (CC) or
gonadotrophins (hMG), patients were randomly assigned to one of the
following groups: group 1 received IUI 24 hours after hCG administration,
group 2 received IUI 32 hours after hCG administration and group 3 received
IUI 40 hours after hCG administration.
OUTCOME: Number of dominant follicles and endometrial thickness on the
day of hCG administration and pregnancy rates.
RESULTS: Forty-five patients underwent 125 IUI cycles: 15 patients were
treated for 42 cycles in group 1, 15 patients for 41 cycles in group 2, and 15
patients for 42 cycles in group 3. The overall pregnancy rates per cycle for
groups 1, 2, and 3 were 14.3%, 17% and 21.4% respectively. There was no
statistical significant difference between the three groups. Pregnancy rates per
cycle in the CC and hMG groups were 12.1% and 23.7% respectively with no
statistical difference between both groups.
CONCLUSION: Our data indicate that IUI can be performed from 24 hours to
40 hours after hCG administration without affecting pregnancy rates and that
both CC and hMG can be used for induction of ovulation; although the 40 hour
insemination and using low dose hMG adds up to a higher chance of pregnancy.
Keywords: Intrauterine insemination, Controlled ovarian hyperstimulation ,
Timing of IUI, Pregnancy rate.