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Abstract Atherosclerosis is the main cause of death and cardiovascular (CV) complications in end-stage renal disease (ESRD). A possible explanation is that decreased renal function may be associated with other nontraditional risk factors, and genetic factors. This study involved 40 end stage renal disease patients and 30 age- and sex- matched healthy control subjects. All were subjected to Full history taking, full clinical examination, kidney functions & genotyping of the ”Leu 554 Phe” polymorphism in the E-selectin gene, Doppler examination of the carotid artery (for the patient group only). The CT (heterozygous) genotype is the more prevalent genotype in our small studied groups and the presence of the T allele might not carry the risk of atherosclerosis in ESRD patients. Key words: Chronic kidney disease, Atherosclerosis, E-selectin. |