الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
 |  | from | 59 |  |  |
| | | from | 59 | | |
Abstract
The aim of this work was to compare between serum iron parameters in,preeclampticversus normotensive pregnancy while the ultimate goal to detect the role of these in the etiology and pathogeneses of preeclamsia.
One hundred women during the third trimester were included in this study and divided into the following: Group I includes 50 pregnant women with preeclampsia and was further subdivided into: Group A: Includes 25 patients with mild preeclampsia. Group B: Includes 25 patients with severe preeclampsia and group II: includes 50 pregnant women with uncomplicated pregnancies (the control group).
Our results summarized that:
- The mean age in mild preeclampsia was 24.92±4.11 and in severe preeclampsia was 25.11±5.0, finally in control group mean age was 26.14±4.45, on comparing the studied groups it was found that there was no significant difference between the two studied groups regarding age.
- Mean gestational age in mild preeclampsia was 37.04±1.51, and in severe preeclampsia as 34.76±3.13 and in control group was 38.76±1.61 weeks, on comparing the two studied groups it was found that there was a significant increase in gestational age in control group more than severe and mild preeclampsia, on the other hand there was a significant difference between mild and severe preeclampsia also.
- There is high significant statistical comparison between the three studied groups as regards SBP&DBP.
- Regarding edema the positive cases were 24 (96.0%) in mild preeclampsia, the positive cases were 25 (100%) in severe preeclampsia and in control were 6 (12.0%). There was significant difference between the three studied groups regarding edema.
- In Urinary albumin, positive urinary albumin cases were 25 (100%) in mild preeclampsia and in severe preeclampsia were 25 (100%). There was significant difference between the three studied groups regarding urinary albumin.
- Regarding CBC, it was found that there were non significant statistical comparison between the two studied groups as regards Hb, PT and PTT. While there is high significant statistical comparison between the two studied groups as regards platelets count.
- In this study, we did not find any significant differences in haemoglobin concentrations when compared these results among pre-eclamptic and normal pregnant women. This finding rules out red blood cell hemolysis as a cause of increased serum iron levels in pre-eclamptic women.
- Increased maternal erythropoietin levels in women with preeclampsia is a result of placental function and not of decreased renal perfusion or hemolysis.
- A decreasing maternal platelet count is considered as an early sign of worsening of preeclampsia and may occur even before other clinical manifestations of the disease are apparent. The pathogenesis of thrombocytopenia in women with severe preeclampsia is unknown, although vascular endothelial damage, impaired prostacyclin production and increased deposition of fibrin within the vascular bed have been suggested. Accelerated platelet destruction, platelet activation, increased platelet volume and increased megakaryocyte production have been observed.
- In this study the platelet count was found to be significantly lower in group 1(especially in the severely preeclamptic women) than the normal pregnant women group.
- There is non significant statistical comparison between the two studied groups as regards Creatinine and there is no significant statistical comparison between the two studied groups as regards AST& ALT.
- In TIBC the mean in mild preeclampsia was 419.12±110.57and in severe preeclampsia was 343.92±94.38, finally in control group, the mean was 517.56±63.58, on comparing the two studied groups it was found that there was significant difference between the three studied groups regarding TIBC.
- In ferritin the mean in mild preeclampsia was 36.75±6.53 and in severe preeclampsia was 193.49±233.09, finally in control group, the mean was 12.32±6.20, on comparing the two studied groups it was found that there was highly significant difference between the two studied groups regarding ferritin.
- There is evidence that increased serum iron level plays a pathogenic role in the development of preeclampsia. Iron status markers such as serum iron and ferritin perform as an acute phase reactant. Whether serum ferritin in chronic inflammatory disease acts as an acute phase reactant or not is a controversial issue.
- Since iron stores are already depleted, release of iron from ferritin as a result of liver damage may not contribute to the raised serum iron level in preeclampsia.
- In uric acid the mean in mild preeclampsia was 5.22±1.51 and in severe preeclampsia was 6.57±1.18 finally in control group, the mean was 4.31±1.47,on comparing the two studied groups it was found that there was significant difference between the two studied groups regarding uric acid.
- The increase in serum uric acid levels was directly prportional to the severity of the disease, attributed this to glomerular pathology, a well known component of preeclampsia, and which correlates with the degree of hyperuriceamia.