الفهرس 
T-Regulatory CellOnly 14 pages are availabe for public view
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Abstract
Allergic asthma is classified as a type 1 hypersensitivity
reaction. This involves allergen-specific immunoglobulins of
the IgE class bound to high-affinity Fcε receptors on the
surfaces of basophils and mast cells present in the subepithelial
layer of the airways. The airway hypersensitivity is normally
suppressed by regulatory T cells, which maintain airway
tolerance and represent a major pathway proposed to contribute
to the maintenance of immune homeostasis in the airways.
Bronchial asthma can result from a loss of regulation of
autoreactive T cells. Failures of T reg cell-mediated regulation
include: inadequate numbers of T reg cells owing to their
inadequate development, proliferation or survival; defects in T reg
cell function that is intrinsic to Treg cells; and resistance of
pathogenic effector T cells to suppression by T reg cells owing to
factors that are intrinsic to the effector cells or factors that are
present in the inflammatory milieu and that support effector T cell
resistance. DC, interleukin; TGFβ, Th17.
The aim of the present study was to determine circulating
T regulatory cells defined by the CD4, CD25, protein Foxp3 in
the peripheral blood and their role in the severity evaluation of
bronchial asthma in children.