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Abstract Adenomyosis is a common non neoplastic gynecologic disease characterized by the presence of ectopic endometrium within the myometrium. The MR appearance of adenomyosis may occasionally fluctuate in response to hormonal stimulation and treatment . Therefore, MR imaging for the evaluation of a uterine myometrial lesion should be performed in the late proliferative–secretory phase .MR imaging is helpful not only in monitoring the treatment effect of hormonal therapy, but also in predicting the therapeutic effect. Adenomyosis typically presents as either diffuse or focal thickening of the junctional zone or an ill-defined area of low signal intensity in the myometrium on T2-weighted MR images. Occasionally, the islands of ectopic endometrial tissue can be identified as punctate foci of high signal intensity. Less commonly, adenomyosis can present as a well circumscribed form known as adenomyoma , adenomyotic cyst (characterized by the presence of haemorrhagic cyst) , or adenomyomatous polyp protruding into the uterine cavity. In cases of endometrial cancer in the uterus with adenomyosis, evaluation of myometrial invasion may become difficult. Rarely, endometrial cancer may arise directly from adenomyosis resulting from malignant transformation of endometrial glands, and this causes diagnostic challenges. |