الفهرس 
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Abstract
This study four surveys (January, April, July and October, 2008) were undertaken to investigate the bioaccumulation of Cd, Pb and Ni in the liver, kidney, gills, skin and muscles of both sexes of Clarias gariepinus from the River Nile south (Al-Aiat) and north (Barrage) areas of Cairo. Metals bioaccumulation and serum gamma glutamyl transferase (g-GT), alkaline phosphatase (ALP), urea, uric acid, creatinine, thyroxine (T4) and triiodothyronine (T3) were analyzed then applied to differentiate between the concentrations found at the two locations, between all of the surveys, and the two sexes. Comparison of these studied elements concentrationsin water between the two sites. The greatest concentration of Cd was detected in the skin. The concentrations of Pb and Ni were highest in the kidney followed by the skin. Lead and Ni concentrations increased in fish collected from Barrage area than that from Al-Aiat area. Gills is the more tissue that affected by season. The correlations between the three elements revealed:- Both sexes of C. gariepinus showed significant positive correlations between the Ni and Pb concentrations in both liver and kidney. Nickel concentration demonstrated significant positive correlation with the Cd concentration in the skin of female fish. Very highly significant positive correlation was detected between the Ni concentrations in the gills and kidney of male fish. Significant positive correlations were calculated between the Pb and Cd concentrations in the
skin of both sexes; in the muscles of male fish and in the liver and kidney of female ones. Large numbers of significant difference values were detected in the serum biochemical parameters studied:- Location effect appeared more evident with serum ALP and urea and to lesser degree with serum creatinine. Serum g-GT and uric acid were the lowest parameters affected with the location of samples. Serum g-GT, ALP, urea and uric acid were affected by fish sex, while serum creatinine showed no
significant sex change. Serum g-GT did not show any significant seasonal change in this study. The multiple linear regression analysis between thethree heavy metals accumulations in the five organs and the serum biochemical values revealed that the variations in these values are as
follows: 6 – 9 %; 23 %; 6 – 11 %; 53 %; 29 % and 30 % for the serum - GT; uric acid; creatinine; T3; T4 and T3/T4 ratio respectively.