الفهرس | Only 14 pages are availabe for public view |
Abstract Verrucae are benign epithelial proliferations induced by several types of HPV. Verrucae plantaris is one of the most common and challenging dermatologic lesions to treat and caused by HPV subtypes 1, 2, 4 and 63. Although there are several topical, systemic and physical methods used in verruca treatment such as cryotherapy, keratolytics, immunotherapy, antimitotic agents, laser therapy (CO2 & PDL), electrosurgery and intralesional injection of antigens, there is no single optimal treatment been determined. All current treatment modalities are associated with their own side effects (substantial pain, tissue destruction, scarring, infection, bleeding, and pigmentary changes) and frequent recurrence. Research is still aiming to find combination treatments, not only to be safer, more effective and more easily applied but also to produce rapid response with less side effects and lower recurrence rate. Salicylic acid is used as a treatment option for wart treatment with varying degrees of success. Recently PDL is used in wart treatment. Its action is based on the specific destruction of superficial dilated capillaries and closure of feeding vessels in warts by selective photothermolysis of oxyhemoglobin within the microvasculature. Several studies have examined the efficacy of (PDL) in treating warts. Cure rates were reported to vary from zero to 100%. The differences between these success rates in previous studies were thought to be due to the differences in the number of the pulses, the density of the energy and the intervals of the therapy used in each study. |