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Abstract Infection is a common, serious complication related to insertion of fracture-fixation devices or prostheses. Although potenti~lly beneficial, the administrations of systemic antimicrobial prophylaxis and compliance with the usual measures to control infection have not completely eradicated infections associated with the use of these devices. An infection a~30ciated with a fracture-fixation device is generally difficult to eradicate without removal of the device and is expensiv(~ to treat due to produce an extracellular polysaccharide matrix (biofilm). This study was performed to demonstrate the incidence of orthopedic implants acquired infections inpatients in the department of orthopedics at Minia university hospital, resistance of isolated microorganisms to different antibiotics, their ability to form biofilm in vitro, degree of bacterial adhesion to certain biomaterials used in orthopedic surgery and the effect of gentamicin, sodium. salicylate each alone and in combinations on the bacterial adherence. A total of 89 bacterial isolates were recovered frGm 83 patients with orthopedic implants (9 prostheses, 36 plates, pins and screws, 181M nails and 20 Illiazarov wires). 67 (80.70/0) Patients had a positive culture, while in 16 (19.30/0) patients, the culture was negative. It was found that 37.30/0 of samples represent mixed bacterial infections while, 62.7% of samples :epresent single bacteri.al isolate. |