الفهرس 
AcknowledgmentOnly 14 pages are availabe for public view
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Abstract
It is generally accepted that rodent pathogens may not only be hazardous for animals (and humans) but can severely influence the results of animal experiments.
The present study was designed to provide a base line information on non-neoplastic and neoplastic lesions occurred in various organs of (79) albino rats and (36) swiss albino mice.
Histopathological examination showed the presence of non- neoplastic and neoplastic lesions throughout the body. In this context, non-neoplastic lesions in the form of cellular degeneration and necrosis, as well as vascular and inflammatory changes were found. Alterations related to some specific infectious diseases were also observed. In addition, primary neoplastic lesions were recorded in liver, kidneys, lungs, skin, subcutaneous tissue, salivary gland and mammary glands. Secondary neoplastic lesions were also found in lung and heart.
Most pounced non-neoplastic histopathological findings in the liver were vacuolar degeneration, necrosis, activation of Kupffer cells, congestion and hemorrhage, thrombosis, angiectasis, abscess, mononuclear cellular infilteration in portal area and hepatic parenchyma, portal fibrosis, central fibrosis, intracytoplasmic inclusions bodies, intranuclear inclusions bodies, syncytia, salmonella- like granuloma and toxoplasmosis.
Neoplastic changes in liver constituted of hepatocellular adenoma, hepatocellular carcinoma and cholangiocarcinoma.
Non-neoplastic changes in the kidneys glomerular necrosis, glomerular hypercellurity, hyaline glomerulopathy, tubular necrobiotic, albuminus cast, interstitial nephritis, suppurative nephritis, renal coccidiosis and nematode in renal pelvis.
Renal adenoma was recorded as neoplastic changes in kidneys.
Major non-neoplastic pulmonary lesions constituted of alveolar emphysema, anthracosis, mucopurulent bronchopneumonia, fibrinopurulent bronchopneumonia, suppurative bronchopneumonia, fibrinous pleuro pneumonia, interstitial pneumonia, congestion, thrombosis and hemorrhage.
The neoplastic changes in lung revealed bronchoalveolar carcinoma, metastatic tomour in the form of hemangiosarcoma and salivary gland adenocarcinoma.
Cardiac non-neoplastic lesions formed of degeneration and necrosis of myocardial fibers, interstitial mononuclear cellular infilteration, congestion and hemorrhage, perivascular edema, fibrinoid necrosis in wall of blood vessels.
Metastatic tumour in heart revealed hemangiosarcoma.
Non-neoplastic changes in intestine revealed enteritis in form of necrotic, fibrinonecrotic enteritis and chronic enteritis. Abscess could be observed in intestine. There were also coccidiosis and nematode infestation in intestine.
Non-neoplastic lesions in brain were demylination, neuronal degeneration and necrosis, gliosis and satellitosis, congestion and hemorrhage, perivascular edema and lymphocytic cuff, fibrinopurulent meningitis and toxoplasmosis.
Non-neoplastic changes in skin revealed hyperkeratosis, epidermal ulcer, dermatitis, abscess formation and mite infestations.
Neoplastic changes in skin revealed squamous cell carcinoma, sebaceous gland adenocarcinoma, hemangiosarcoma. Fibrosarcoma could be observed in subcutaneous.
The present study reported other neoplastic lesions in form of adenocarcinoma in salivary gland, fibroadenoma and adenocarcinoma in mammary glands.