الفهرس 
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Abstract
Antiphospholipid antibodies, in addition to causing pregnancy loss and recurrent miscarriage, may present as biochemical pregnancies or infertility due to the effects on the trophoblast in addition to the effect on clotting. At present, there is insufficient evidence to recommend routine testing for aPL in infertility. However, the identification of β2GP1-dependant antibodies and antibodies in addition to ACA and LA may allow us to identify certain subgroups in the future in whom aPL may be relevant, and in whom effective treatment can be used. However, this diagnosis will also be dependant on the diagnosis of embryonic normality, which is almost impossible to diagnose at present (Carp & Shoenfeld, 2007).
The present study was aimed to show the relationship between unexplained infertility and seroprevelance of immunoglobulin G of anticardiolipin antibody.
This study was a case-control study on 140 women matched for age(20-35 years) were sub-divided into two main groups as follow:
Group (I): (Study group) included (80) patients with the diagnosis of unexplained infertility.
Group (II): (Control group) included (60) age matched, fertile women coming to Family Planning Clinic.
Unexplained infertility was diagnosed by the following:
• Absence of male factor: Normal semen analysis: ≥ 20 million sperm per mL, with more than 50 percent of the sperms showing forward motility, and more than 30 percent normal morphology.
• Adequate ovulation based either on a mid-luteal serum progesterone level greater than 10ng/mL, or serial transvaginal ultrasounds to monitor the development and rupture of a dominant ovarian follicle.
• Normal FSH, LH, TSH, PRL.
• Apparently normal uterine cavity and patent tubes as proved by hysterosalpingography.
• Normal laparoscopic findings.
The exclusion criteria that not included in this study during selection of patients of group I was:
1. Women with a known cause of infertility.
2. Women with gross pelvic pathology.
3. Women with uncontrolled chronic disease e.g. Hypertension, DM.
4. Women with immunological disease e.g. SLE.
5. Women with history of chronic Pelvic inflammatory disease.
6. Patients with previous arterial and/or venous thrombosis. Subjects with first degree relatives with arterial and/or venous thrombosis before 65 years old will be also excluded
A full history and clinical examination was carried out for each patient with a written consent taken from every patient to participate in the study.
A venous blood sample (5 ml) was collected from every participant at any day of the menstrual cycle. Samples were left to clot, then centrifuged for 10 min at 2.500rpm and serum was separated and stored at -20°C till the time of analysis. Anticardiolipin IgG levels were assayed using : CORGINX ELISA KIT.
The current study showed that there was a highly statistically significant difference (P<0.001) as regards parity and age of menarche between the 2 studied groups. Also it has been found that there was a statistically significant difference (P<0.05) between the two groups as regards age, duration of marriage and BMI.
This study has shown that the number and percentage of seropositive and seronegative patients for anticardiolipin antibody IgG in both studied groups was [15(10.71%), 125(89.29%)] respectively.
The current study has shown that there was a highly statistically significant difference between the two groups (P<0.001) as regard to the level of IgG of anticardiolipin antibody, as mean values of anticardiolipin antibodies in two groups was (12.040±8.49) and (7.06±2.84) respectively.
The present study has shown that the number of patients of group I who were seropositive for anticardiolipin antibody IgG was 15 and its percentage was (18.75%), while the number and percentage of seronegative for anticardiolipin were 65 (81.25%) and this difference was a highly statistically significant (P<0.001).
The current study found that there were no statistically significant difference between the two subgroups (seropositive and seronegative ) in the infertile group as regard age , duration of marriage, menarche, duration and cycle of menstruation, day of sample taken from the cycle and BMI. Also it found that there were no statistically significant difference between the two subgroups in the infertile group as regard FSH, LH and PRL level. But there was statistically significant difference between the two subgroups as regard TSH level.
The present study found that there were no statistically significant correlation (p>0.05) between age, duration of marriage, age of menarche, BMI and anticardiolipin IgG level among patient group (Group I).