الفهرس | Only 14 pages are availabe for public view |
Abstract In vitro,as well as in vivo antimicrobial agent(AMA)resistance in typhoid fever for drug of choice(DOC) e.g.cidocetin(chloramphenicol 82.9% )&septazole(co trimoxazole 8.6%) the main drugs to be used in tropical hospitals&may became the sole regime in the treatment of such cases in the Governmental Hospitals & in private sector.Therefore,the treatment pattern failure becomes general problem in the management of typhoid fever.Resistance to antimicrobial agents,mediated by various mechanisms,plays an important role in the failure of antimicrobial agent-based treatment of various infectious diseases.As a result,these diseases re-emerge rapidly hence the endemicity Antimicrobial agents therapy may be altered accordingly, this resistance may be tailored by using new groups of AMAs for e.g. third generation cephalosporins (CTX 11.4%,CEP 5.7%,CRO 2.9%) and /or quinolones (CIP,NOR 0% and NA 2.95%) According S.typhi and S.paratyphi resistance profile the least effective AMA was C followed by Amp and there resistance ratio were 86% & 82 % respectively. The most potent AMAs in this study were 100% active CIP, NOR,GN and surprising TE.Some AMA patterns repeated with many isolates such as (AMP- C)which posses resistance to 17(48.6%) also (AMP-AMC-C)that repeated with 6(17.1%).While (AMP-C-FOX) in 5(14.3%) and (AMP- C-AMC-S) in 2 (5.7%). |